The World Health Organization (WHO) documented a sharp rise in yellow fever cases across five American Countries from late December 2024 to April 26, 2025. A total of 212 confirmed infections and 85 related deaths have been documented, indicating a 40% case fatality rate.

Brazil has recorded the highest toll, with 110 cases and 44 deaths, followed by Colombia with 60 cases and 24 deaths. Peru, Ecuador, and Bolivia have also reported confirmed cases, with fatalities occurring in each country.

Unlike in 2024, when cases were mostly confined to the Amazon region, 2025 has seen the spread into new areas such as São Paulo in Brazil and Colombia's Tolima department.

National health authorities have ramped up responses, including immunization drives, stronger surveillance, and preventive strategies.

WHO has classified the situation in the Americas as a serious public health concern, citing the spread beyond the hotspots, uneven vaccination coverage, and limited vaccine availability.

The organization stresses the urgency of enhanced surveillance, prompt diagnostics, cross-border cooperation, and expanding vaccine access to curb the disease's reach. Vaccination remains the key tool in preventing yellow fever outbreaks.