• The 43rd Multi-Country Mpox Situation Report, issued by WHO on December 9, 2024, underscores that Mpox continues to pose a global public health emergency under the International Health Regulations (2005).

• Despite worldwide efforts to control the virus, its spread has escalated, with outbreaks linked to multiple MPXV clades impacting Africa, the Americas, Europe, and the Asia-Pacific.

• Since 2022, over 115,000 cases and 255 deaths have been reported across 126 countries. 

• Recent developments include Angola’s initial cases and travel-related infections identified in Canada and the United States.

• The Democratic Republic of Congo (DRC) remains a focal point, with widespread clades Ia and Ib MPXV transmission, particularly affecting children and young adults.

• WHO has prioritized enhanced emergency coordination, real-time surveillance, scalable healthcare solutions, and equitable vaccine distribution.

• The response continues to evolve through updated vaccination plans, diagnostic advancements, and revised risk assessments, alongside efforts to promote education, reduce stigma, and protect communities.

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