• A case-control study conducted across 26 hospitals in the United States sheds light on the effectiveness of the maternal COVID-19 vaccine in protecting infants<6 months from hospitalization.

• Maternal vaccination status was determined in women who had received at least two doses of the mRNA vaccine, at least one of which happened during pregnancy, or one dose of the viral vector vaccine followed by at least one dose of the mRNA vaccine during pregnancy.

• 377 cases and 339 controls were selected. 

• Vaccine effectiveness (VE) was determined as (1 – adjusted odds ratio) x 100%.

• The VE was: 

1. 35%(15%–51%) among infants aged six months

2. 54%(32%–68%)  among infants aged three months 

• Maternal vaccination significantly reduced the odds of COVID-19-related hospitalization among infants <6 months.

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