• KP.2 belongs to the variant type known as “FLiRT,” which has been derived from the JN.1 variant.

• FLiRT is the term used for a family of different variants that have picked up the same set of mutations.

• FLiRT’s or FLiPs refer to the position of spike protein, which in this case is 456, 346, and 572.

• Two of these mutations, 456 and 346, act by eliminating binding sites for antibodies that neutralize SARS-CoV-2.

• However, in addition to evading antibodies, it has lost some ability to bind to receptors and enter the cells.

• The difference is just one or two amino acids, so there are still a lot of other places where antibodies can bind.

• Fortunately, the JN.1 infection does provide strong protection against all FLiRT variants.

• After years of vaccination and infection, most people can fight off an infection without much concern.

• The period of infectiousness remains the same as in JN.1 and previous Omicron variants.

• It is contagious 1-2 days before developing and a few days after symptoms subside.

• It is recommended to test oneself if one is feeling sick, which will help in early diagnosis and appropriate treatment.

• Since this variation has the potential to have a severe impact on the susceptible population, extreme caution should be exercised.

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