• A case-control research was undertaken to explore benefits of metformin use for MPN, using population registries of Denmark.

• People diagnosed with MPN between 2010-2018, were taken as cases and controls were selected from the Danish general population matched for age and sex.

• Metformin use data was secured from the country’s National registry of prescriptions.

• History of Metformin use in Cases before their diagnosis of MPN was determined and compared with the age-sex matched control group to estimate adjusted odds ratio to check association between metformin use and MPN.

• The study concluded that odds of MPN was significantly lower in those with a history of metformin use. [OR: 0.84 (0.73-0.96)]

• Furthermore, the strength of association displayed a significant dose-response relationship with rising treatment durations and these results were consistent in both sexes and all age groups.

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