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Racial and gender disparities in carbapenem-resistant Enterobacterales infections

Content Editor: Dr. Gurumurthy

May 7, 2024 at 12:30:00 PM

Antibiotic resistance, Racial difference

Content Editor: Dr. Gurumurthy
  • The study conducted by Ruffin et al., from April 2016 to November 2019, involved 362 patients hospitalized in U.S. hospitals with bloodstream infections (BSI) caused by carbapenem-resistant Enterobacterales (CRE).

  • These 362 encompassed both Black and White racial groups.

  • The findings indicated that Black females were more likely to be admitted from long-term care facilities and had higher rates of heart infections.

  • In contrast, Black males were generally younger and more prone to cerebrovascular disease.

  • Among the Whites, malignancy was the reason for the hospital admission of 39% of White males and 39% of White females.

  • The primary source of infection for both Black females (32%) and White males (27%) was often unidentified.

  • An independent predictor of 30-day mortality was the interaction between sex and race (p=0.016).

  • Notably, Black females exhibited a higher 30-day mortality rate compared to Black males (adjusted odds ratio (aOR) - 2.59, 95% CI 1.02 - 6.56) and White females (aOR 2.15, 95% CI 1.01 - 4.58).

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