Kerala has initiated Operation AMRITH which stands for "Antimicrobial Resistance Intervention for Total Health to Combat Antimicrobial Resistance (AMR)" by enforcing the H1 rule, requiring a doctor's prescription for all classes of antibiotics.

The public is encouraged to report any instances of pharmacies providing antibiotics without a prescription and pharmacies are required to display posters emphasizing the requirement of a prescription.

This step is facilitated by Kerala's high doctor-patient ratio and literacy rate, which promotes compliance.

However, the impact of this initiative on drug-resistant infections may take years to materialize.

Overprescription persists due to inadequate diagnosis and patient pressure.

Kerala also emphasizes disclosing hospital-acquired infection rates and improving infection prevention standards.

Further measures include: