Ten African countries reported Clade Ib mpox transmission over six weeks. The Democratic Republic of the Congo has the highest number of confirmed mpox cases in Africa for 2025, although reporting is incomplete due to limited testing resources.

Uganda is seeing a reduction in cases, yet it still reports approximately 200 cases weekly. In Burundi, cases have decreased to fewer than 50 per week, while Sierra Leone has experienced a surge, with over 600 cases reported last week, mainly among young adults in urban regions.

Across Africa, more than 720,000 doses of the MVA-BN vaccine have been administered, with 81% of these in the DRC. Australia has recorded its first clade Ib case, traced back to travel from Thailand.