• Between 9.3 million and 41 million infections, 100,000 to 710,000 hospitalisations, and 4,900 to 51,000 deaths are attributed to seasonal influenza in the United States each year.

• Since 2003, the FluSurv-NET system has tracked these hospitalizations, offering information on patient demographics, clinical traits, and results.

• Children under the age of five and those over 65 had the greatest hospitalization rates. Obesity, chronic lung disease, and cardiovascular disease were among the underlying medical issues that affected a sizable percentage of hospitalized patients.

• For the 2013–14 and 2022–23 influenza seasons, the lowest vaccination rates were among adults aged 18–49, while the highest vaccination rates were among those aged 65 and older. The lowest vaccination rate was 29.3% in 2022–2023.

• In recent seasons, the most often used influenza test type was a molecular assay, specifically multiplex conventional molecular tests. Between 2018–19 and 2022–23, the percentage of FluSurv-NET patients who had acute respiratory signs and symptoms at hospital admission dropped from 90.6% to 83.2%.

• In order to address health inequities, the report emphasizes the significance of influenza vaccination and antiviral therapy, particularly for high-risk groups, as well as the necessity of continuous surveillance.

• In general, hospitalized individuals have poor vaccination rates. In order to lessen the impact of influenza on public health, the data from FluSurv-NET highlights the burden of hospitalizations related to influenza in the United States and the necessity of ongoing surveillance and vaccination campaigns.

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