• A 7-year-old male child who suffered from Primary Combined Immunodeficiency (PID) caused by a mutation in the ARPC1b gene was treated using an extraordinary novel technique.

• A gene that is a key component of the cytoskeleton is necessary for the formation of immune synapses, endocytosis, and phagocytosis of Ag-presenting cells.

• This type of immunodeficiency is usually diagnosed by genomic sequencing and treated with a hematopoietic cell transplant (HCT) from an HLA-matched healthy sibling.

• One of the greatest achievements of the Dept. of Hematology and Stem Cell Transplantation at Army Hospital R&R was the first successful orchestration of a bone marrow transplant from a Matched Unrelated Donor (MUD).

• Bone marrow harvested from a voluntary, unrelated donor from DATRI was infused into the patient’s bloodstream after destroying his defective cells with high-dose chemotherapy.

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