• A randomized trial published in The Lancet Infectious Diseases revealed that a mango-flavored tablet combining ivermectin and albendazole is more effective against soil-transmitted helminth (STH) infections, especially Trichuris trichiura (whipworm), than albendazole alone.

• The study, involving 1,001 children in Ethiopia, Kenya, and Mozambique, showed cure rates of 97.2% for a three-dose regimen (FDCx3) and 82.9% for a single dose (FDCx1), compared to 35.9% for albendazole alone. The treatment was safe, with mild gastrointestinal side effects resolving within 48 hours, and was well-accepted by children for its taste, smell, and texture.

• The fixed-dose combination (FDC) also holds promise for treating Strongyloides stercoralis, which is resistant to albendazole but responsive to ivermectin. Researchers believe this FDC could enhance STH control efforts, supporting mass de-worming programs and individual treatments, potentially redefining global elimination goals. Further studies are planned to evaluate its broader implementation in endemic regions

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