• Researchers at the Harvard T.H. Chan School of Public Health have developed an approach to malaria control by targeting Plasmodium falciparum within mosquitoes, rather than the mosquitoes themselves. 

• Among 81 antiparasitic compounds tested, 22 significantly impeded parasite development, with two compounds achieving complete eradication even at low concentrations. 

• These compounds retained efficacy for over a year and prevented infection when mosquitoes were exposed up to four days prior. 

• This strategy could address insecticide resistance and be cost-effectively integrated into existing bed nets. This method represents a substantial advancement in malaria prevention, particularly in regions where malaria is endemic and insecticide resistance poses challenges.

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