Based on the findings of a systematic review and meta-analysis of available evidence (283 studies), WHO suggested that non-sugar sweeteners (NSS) are not to be used as a means of achieving weight control or for reducing the risk of noncommunicable diseases.

This recommendation applies to all except individuals with pre-existing diabetes and includes all synthetic and naturally occurring or modified non-nutritive sweeteners that are not classified as sugars. 

Common NSS include acesulfame K, aspartame, saccharin, and sucralose; they neither are essential dietary factors nor do they have any nutritional value.  

Research points out that long-term use of NSS could potentially cause an increased risk of type 2 diabetes, cardiovascular diseases, and mortality in adults.