• Lancet recently published the latest findings from Global Burden of Disease (GBD) 2021 as a series of articles.

• GBD 2021 findings are based on an analysis of 371 health conditions from over 100,000 data sources, including national disease registries, census, and autopsies.

• The rise in Disability Adjusted Life Years (DALY) from 2010 to 2021 was mostly due to a rise in population and aging.

• This latest GBD 2021 series features health impact due to COVID-19 for the first time in GBD findings.

• Between 2010-2021, DALY increased substantially for anxiety disorders, depressive disorders, and diabetes.

• While, communicable, nutritional, maternal, and neonatal diseases have shown a decrease of 13%, HIV- AIDS has shown a 48%, and Diarrheal illness has shown a 47% decrease in age-standardized DALY.

• In 2021, COVID-19 was the biggest cause of DALY, followed by Ischemic heart disease.

• Globally, Healthy life expectancy (HALE) improved slightly from 61.3 in 2010 to 62.2 in 2021.

• Regardless of age and gender, the top 3 causes of YLDs in 2021 were all non-communicable diseases: Low back pain>Depression>Headaches.

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