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Challenges to the 3HP TPT regimen.

Content Editor: Dr Sumana Mukhopadhyay

November 28, 2023 at 12:30:00 PM

TPT, Tuberculosis, Latent TB

Content Editor: Dr Sumana Mukhopadhyay
  • After the nationwide launch eight months ago by Prime Minister Narendra Modi, the 3HP TB preventive treatment rollout is experiencing delays in drug supply to states.

  • Despite the delays, Tamil Nadu and Kerala have taken the initiative to implement 3HP for TB preventive treatment for all recently diagnosed contacts.

  • The 3HP regimen, involving once-weekly isoniazid-rifapentine for 12 weeks, offers a more manageable and economical course with 12 doses compared to the current daily isoniazid treatment requiring 180 pills.

  • This therapy is very beneficial to contacts, as around 20% of TB can be traced back to home exposure.

  • It can also stop the progression of highly prevalent latent TB for a long period of time.

  • Dr. Padmapriyadarsini underscores the benefits of 3HP, such as:

  1. Enhanced compliance

  2. Reduced adverse effects

  3. Higher completion rates

  4. Cost-effective

  • TPT is a high-reward project that needs more attention and investment to tackle tuberculosis.

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