Challenges to the 3HP TPT regimen.
Content Editor: Dr Sumana Mukhopadhyay
November 28, 2023 at 12:30:00 PM
TPT, Tuberculosis, Latent TB

After the nationwide launch eight months ago by Prime Minister Narendra Modi, the 3HP TB preventive treatment rollout is experiencing delays in drug supply to states.
Despite the delays, Tamil Nadu and Kerala have taken the initiative to implement 3HP for TB preventive treatment for all recently diagnosed contacts.
The 3HP regimen, involving once-weekly isoniazid-rifapentine for 12 weeks, offers a more manageable and economical course with 12 doses compared to the current daily isoniazid treatment requiring 180 pills.
This therapy is very beneficial to contacts, as around 20% of TB can be traced back to home exposure.
It can also stop the progression of highly prevalent latent TB for a long period of time.
Dr. Padmapriyadarsini underscores the benefits of 3HP, such as:
Enhanced compliance
Reduced adverse effects
Higher completion rates
Cost-effective
TPT is a high-reward project that needs more attention and investment to tackle tuberculosis.
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