• From 2004 to 2018, 163,250 CVD-free women aged 30 and older completed routine high-risk HR-HPV screening under this study. 

• The average age of the patients was 40.2 years.

• Overall, 9.2% were infected with HR-HPV, and all had low traditional CVD risk factors.

• During 1.4 million person-years of follow-up, 134 women died of CVD, with 16% being HR-HPV-positive.

• After adjusting for CVD risk variables and potential confounding factors, infected women had risks of atherosclerotic CVD (ASCVD), ischemic heart disease, and stroke death that were 3.91, 3.74, and 5.86 times higher than their uninfected peers, respectively.

• The study's findings, along with other research linking viruses like HPV to higher CVD death rates, "make a strong case for accepting viruses as risk factors for adverse outcomes from ASCVD."

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