The Eurasian H5N1 clade was first detected in US poultry and commercial stock in early 2022.

Since October 2022, cases have spiked, and outbreaks have been reported in backyard flocks, poultry families, and commercial bird producers.

The USDA and Animal and Plant Health Inspection Service report that this wave of rise in cases crossed the record 60 million mark in November 2023.

The first commercial farm outbreak was reported from a gamebird producer in Alabama, which houses 296,500 birds.